It seems that Bruce had a positive relationship with his parents' before their deaths. One of his happiest memories was being taken to the Monarch Theater on a regular basis to see his "favourite movie". After his parent's died at the hands of Joe Chill, Bruce decided to avenge them by becoming the vigilante Batman. However, twenty years after their deaths, he learnt their ties to Falcone and Hill, two of the men he considered the worst of criminals in Gotham. Although he was reluctant to believe these, he would after finding evidence in Falcone's office. Although Bruce still loved his father, he would accept that he had been wrong about him and set out to right the wrongs made in the Wayne name. However, after learning about his mother's wishes to end his father's actions and expose his ties to Falcone and Hill, Bruce was able to forgive her. It is unknown whether he carried on his crusade as Batman in her memory or to carry on protecting Gotham from criminals, though the latter is more plausible than the former.
Alfred has been Bruce's guardian since his parents died when he was nine years old. Through his care and guidance, Bruce learnt to care for others and the importance of the Waynes in Gotham. When Bruce became Batman, Alfred would help support Bruce in his endeavors as the vigilante, providing advice on how he should operate and the importance of his image outside of the operations. After Bruce learned that his parents were linked to corruption through an photo in Falcone's office, in which he saw Alfred attending a meeting with them, he felt betrayed and, if the player chooses to, not forgive him for keeping this information from him. Never the less, Alfred would stay faithfully by Bruce's side and continue to help him as he fought the Children of Arkham.
Bruce held Gordon in high regard, due to his incorruptible nature and stance against it within the precinct. Due to this, he was often Batman contact within the GCPD and would often send locations of crime scenes to him directly. As Wayne, he and Gordon would often associate and perform minor favors for each other, such as giving in evidence against Falcone or arranging to see the crime lord whilst he was in custody. Gordon and Bruce would also work together during Harvey Dent's militarization of the city and, if the player chooses to stop the mayor during his attack on Wayne Manor, the arrest of Oswald Cobblepot.
As Batman, their relationship was purely professional, though Gordon held the vigilante in high regard, especially during Dent's reign as Mayor. Though he did mistrust the vigilante and wouldn't expect him to follow the rules, Gordon saw him as a force of good within the city. However, Gordon would also question his use of violent means, particularly after he brutalizes Falcone and interrogates Hill.
Bruce, as Batman, first meets Catwoman during an attack on the Mayor's office. The two initially spar, due to their differentiating morals. After meeting as their civilian identities, the two were easily able to deduce that the other's double life, due to the injury they inflicted. Bruce's relationship with Selina can mainly depend on the options chosen by the player. If polite to her, it will improve whilst acting antagonistic may cause tension with her. After Bruce tips her off about the Penguin's attack, she will help him during the Children of Arkham's attack on the Mayoral Debate. When Selina is wounded and attacked by members of the group, Batman can choose to save her from members of the group instead of Harvey Dent; this will improve their relationship.
After he is almost killed by Lady Arkham, Selina will save Bruce's life and brings him to her apartment to recuperate. During his time there, Bruce and Selina may, if the player chooses to, engage in a one-night stand, though this may possibly lead to a romantic relationship. He may also open Wayne Manor up for her to hide from Harvey and his enforcers, but she will leave shortly afterwards, fearing that he will not be able to protect her from Harvey's wrath. If Bruce suggests that Selina leaves Gotham, she will contact him shortly afterwards to make sure he is fine, regardless of whether he slept with her or not. This implies that she may have some feelings for him.
After Selina is caught breaking into Wayne Enterprises to steal a prototype, she will hand it back. She claims to have gotten close to him in order to steal from the company and be nothing more than a thief. If Bruce chooses to regard her as more than a thief, she will ask why, where he can choose to mention how fighting with her felt good, how she saved his life or profess his feelings towards her. If the latter is chosen, or he chooses to regard her as nothing but a thief, she will leave, considering him "just like everyone else", meaning their relationship might have been damaged further. However, if the former options are chosen, the two's relationship will improve, with Bruce able to hug or kiss her goodbye, depending on what happened in her apartment. She will also send Bruce a blank postcard with a cat after his defeat of the Children of Arkham, though this will only take place if he regarded her as more than just a thief.
Lucius was one of the people in Wayne Enterprises that Bruce trusted with his private life as the vigilante Batman. As well as provide technical support and gadgets, Lucius would support him during the scandal with his parent's ties to Gotham's underworld, even after he was forced to leave the company. He also personally designed many of the gadgets used by Batman in the field, including the Batsuit, many of the handheld gadgets and the Batcomputer. Whenever he needed technical support or a second opinion on devices/tech, Bruce would contact Lucius for help. However, this would lead to his tragic death, when he handed him a puzzle from the Riddler, that contained a radio emitter and allowed it to play long enough to summon a missile. Following Lucius' demise, he swore to either get revenge on or bring the Riddler to justice.
Bruce's relationship with the mysterious "John Doe" can depend on player choice. Upon his arrival to Arkham, John was the first person to act friendly to him, saving him from some of his father's victims, giving him information on Lady Arkham and helping him organize an escape from the asylum. Bruce can either trust "John", agreeing to lend him a favor when he gets out, or not do so.
Bruce Wayne turned to Vicki Vale for guidance and support for damage control of his family's reputation. However, unknown to him, she was secretly faking her offers to help in order to gain information and try to help destroy his and the Wayne reputation. During the Wayne Enterprises press conference and after his speech, she revealed her true intentions and drugged him, forcing him to attack Oswald Cobblepot. Upon learning she was Lady Arkham, Bruce's views on her can turn antagonistic, though he can wish things had been differently. After learning about the abuse she was put through by the Vales, he can sympathize with and try to reach out to her.
Harvey was one of Bruce's closest friends and would often help him wherever possible. Bruce himself would sponsor Harvey's campaign for Mayor against Hamilton Hill. Following the allegations against the Wayne family, Harvey was forced to separate himself from Bruce, though was reluctant to do so. However, following his injection with the Arkham Drug and catching Bruce in Selina Kyle's apartment, he believed that Bruce had betrayed him and began a smear campaign against his old friend. Harvey would even go as far as send two of his enforcers to murder him, if Bruce tries to talk to him as himself. If the player chooses to stop Penguin from hacking the Batcomputer rather than stop Harvey from taking Wayne Manor, they will confront him and try to talk him out of harming civilians. If they are successful, Harvey will finally see the error of his ways and try to commit suicide. There might also be hope for Harvey to recover if this is the route taken, as Harvey's dominant personality will warn Bruce that they might not be able to control that part of him.
Harvey's relationship with Batman will change depending on choices made in the episodes. If he is saved from disfigurement at the Penguin's hands, he will hold the vigilante in high regard and will support his methods of justice. However, these will be turned if Batman confronts him in following his announcement to seize Wayne Manor and/or confronts him whilst trying to do so. If Batman doesn't save Harvey from Penguin, he will blame the vigilante for his disfigurement and believe that his methods are not as extreme enough. Should Batman confront Dent in Wayne Manor, resulting in the left side of his body being hideously burnt, he may put more blame on the vigilante.
Oswald and Bruce were once childhood friends, the two growing up together as close friends. However, after Oswald's mother was unjustifiably committed to Arkham Asylum by Thomas Wayne, he would come to see his old friend and family as corrupt to the core. Though on initial meeting, Oswald showed no ill favor towards Bruce, he would work behind the scenes with the Children of Arkham to take down the Wayne family and tarnish their legacy.
Bruce's feelings towards Oswald may be antagonistic, depending on the player's choice, or friendly, even during Oswald's take over of Wayne Enterprises. However, he showed concern over his friends decisions and would try to stop him and the Children of Arkham as Batman. However, as Batman, he will be aggressive towards the Penguin and antagonistic towards each other. Depending on who Bruce defeats Oswald as, the criminal's anger may be directed either towards him personally or Batman for either breaking his leg or possibly crippling him.
Batman first encountered the Riddler at the Virago Casino, where he threatened the lives of Rumi Mori and a number of patrons. Having known about Riddler's activities during his father's rule over Gotham, Bruce refused to tread lightly and acted whenever confronting the criminal. He would also swear to either get revenge on or bring him to justice after he killed his ally and friend Lucius Fox. Whenever Riddler threatened the lives on the agents, Batman can choose to go through with his games, resulting in the deafening of one of them, or refuse to, resulting in one or two agents' deaths. It is unknown what Batman would have done to the Riddler if he had not been assassinated by the Pact, but it's likely he would have gone through with what he had decided to do upon Lucius' death.
Bruce's relationship with Falcone depends on the decisions made during dialogue. At first, Falcone will appear calm and friendly. However, if the player chooses dialogue that does not support the mob boss or refuses to perform polite gestures to the mob boss, like shaking his hand in public, he will become increasingly aggressive towards them. However, if they do the opposite, Falcone will show more respect towards Bruce. Despite all this, Falcone still considers Bruce as family, even discussing his father's dealings openly after Bruce learns about them.
However, as the Batman, Bruce will act aggressively and violently towards the crime lord. However, if the player chooses to, he can show restraint from excessive violence, such as refusing to brutalize him but arrest him. Falcone was also more willing to speak under interrogation from Batman than Bruce.
Like Falcone, Bruce's relationship with Hill depends on both dialogue chosen and decisions made. If the player decides to talk to the Mayor as themselves, they will begin discussion neutrally, though Hill is surprised that he finally comes to meet him at this time. Depending on the options chosen, Bruce can be friendly with Hill, offering his friendship and caution around the Penguin, or antagonistic, criticizing him for his links to crime and handing over information to the Children of Arkham. However, Hill is willing to hand over information concerning his and Thomas Wayne's use of Arkham, if Bruce agrees to cancel funding on Harvey Dent's campaign. If he agrees, Hill shares the information and gives Bruce cufflinks that his father had given him, what he claims to be his last gift to him. However, if Bruce refuses, Hill threatens him to remain silent, even doing so on his allies, including Dent and Gordon.
However, as Batman, Bruce would act aggressively and openly threaten Hill, the severity of which can depend on the player's decisions. Hill was aware of the vigilante's reputation and afraid of him, fearing the vigilante would harm or expose him. Because of this, he was more willing to talk under interrogation by Batman, revealing his and Thomas Wayne's actions. He would also try to call his security guards to deal with the vigilante, hoping they would be able to protect him from the vigilante.
The Zellerbach family went far back with Bruce's family, with their currently known members, Robert and Regina Zellerbach, putting trust in Bruce's decisions, even supporting Harvey Dent and opening a replacement mental health clinic to replace Arkham Asylum. However, after his father's ties to corruption were exposes, they may have lost trust in Bruce and believed that he may have some ties to Falcone's empire. Though Regina tried to fight for Bruce to remain at Wayne Enterprises, she was unable to convince them otherwise. She also promised to help Bruce get back in the company, if he complied with the press event announcing his resignation. It is unknown what the relationship between Robert and Bruce was like, but it can be assumed that it was similar to his with Regina's.